Phentermine vs Contrave

Weight Management Medications – Phentermine vs Contrave

Weight loss medications exist in a variety of forms and operate in a variety of ways. Some of them work by suppressing your appetite. They help you feel less hungry and less distracted by food cravings, which might contribute to overeating. These drugs can help you lose weight by assisting you in controlling your calorie intake. Whereas other types of weight loss drugs work by inhibiting dietary fats’ absorption. They act on your digestive system to limit the amount of fat your body absorbs from your food. These drugs can contribute to weight loss over time by reducing the number of calories from fat that your body absorbs. There are also weight loss medications that aim to boost your metabolism. These drugs help to increase your metabolic rate, which means your body burns more calories throughout the day. By giving your metabolism a little extra push, these medications can potentially assist in your weight loss efforts.

When it comes to weight loss drug options, Phentermine and Contrave are two popular choices that many people turn to for help in their journey to shed those extra pounds. Remember, while weight loss medications can be helpful, they are not a quick fix or a substitute for a healthy lifestyle. Embracing nutritious eating habits, staying active, and making sustainable changes to your overall behavior and mindset will contribute to long-term success in achieving and maintaining a healthy weight. Think of them as helpful tools that assist you in making positive changes to your lifestyle. Both Phentermine and Contrave are usually prescribed for short-term use, as part of a broader weight management plan.

Mechanism of Phentermine

Phentermine works in a fascinating way to support weight loss. When you take Phentermine, it interacts with your brain to help control your appetite. It does this by stimulating the release of a chemical called norepinephrine from certain nerve cells in your brain. This norepinephrine acts on the hypothalamus, which is like the control center for hunger and fullness signals. By increasing the levels of norepinephrine, Phentermine basically tells your brain that you’re not as hungry as you may feel. It helps to reduce those intense cravings and suppress your appetite, making it easier for you to resist the temptation to overeat. It also stimulates the release of dopamine, another neurotransmitter associated with reward and pleasure. This action may contribute to its potential to reduce cravings and improve mood, supporting individuals in their weight loss journey. Moreover, Phentermine increases sympathetic nervous system activity, leading to increased energy expenditure and fat mobilization. This boost in metabolic rate helps individuals burn more calories, further aiding in weight loss efforts. While scientists are still exploring all the intricacies of Phentermine’s mechanism of action, its ability to curb your appetite, enhance satiety, and boost your energy expenditure all work together to support your weight loss goals.

Mechanism of Contrave

Contrave operates through a unique mechanism to aid in weight loss. It is a combination medication consisting of two active ingredients: bupropion and naltrexone. These components work together to target different aspects of weight management.

Bupropion, an antidepressant and smoking cessation aid, affects particular neurotransmitters in the brain, including norepinephrine and dopamine. It helps reduce appetite and food cravings by influencing the reward system and regulating mood. By targeting these brain pathways, bupropion can help control emotional eating and promote a more balanced approach to food. Naltrexone, widely used to treat opioid and alcohol addiction, works by blocking specific opioid receptors in the brain. In the context of weight loss, naltrexone proved to reduce cravings for high-calorie, addictive foods. By blunting the effects of opioids on reward pathways, it can help individuals make healthier choices and resist the urge to indulge in unhealthy foods. The combination of bupropion and naltrexone in Contrave provides a complementary effect. Bupropion helps regulate mood, reduce appetite, and enhance motivation, while naltrexone targets cravings and addictive behaviors related to food.

The precise mechanisms of action for Contrave are still being investigated and understood further. Researchers are continuously studying how these components work together to support weight loss.

Phentermine Vs Contrave – Correlation



In recent studies examining the efficacy of Phentermine in weight loss, compelling findings have emerged. For instance, a study featured in the International Journal of Obesity investigated the effects of Phentermine on 108 participants over a 12-week period. The outcomes were impressive, with participants experiencing an average weight loss of 8.8 kg (19.4 lbs) and a notable reduction in body mass index (BMI) by 3.2 kg/m². The study concluded that Phentermine demonstrated effectiveness in accomplishing short-term weight loss goals. Furthermore, the effectiveness of Phentermine has been substantiated by a comprehensive review published in Obesity Reviews. This review encompassed 29 trials focusing on Phentermine treatment for obesity. The cumulative analysis of these trials revealed a significant mean weight loss ranging from 5% to 10% of initial body weight. Notably, the highest magnitude of weight loss was observed within the initial months of treatment. These findings underscore the potential of Phentermine in facilitating weight loss and improving metabolic parameters. The efficacy of Phentermine can vary among individuals, and its use should be combined with lifestyle modifications such as a healthy diet and regular exercise for optimal results.


While Phentermine can be effective for weight loss, it is important to consider its safety profile. As a stimulant, Phentermine may cause side effects such as restlessness, anxiety, and mood swings in some individuals. Moreover, it is not recommended for individuals with certain medical conditions, including hypertension, cardiovascular disease, and hyperthyroidism, due to its potential impact on blood pressure and heart rate. Consulting a healthcare professional before starting Phentermine is essential to ensure its safe use.



Contrave has demonstrated effectiveness in addressing comorbid conditions such as depression and binge eating disorder, which often accompany obesity. One study published in the New England Journal of Medicine evaluated the efficacy of Contrave in more than 4,500 overweight or obese individuals. The participants received Contrave or a placebo over a 56-week period. The study found that individuals treated with Contrave experienced a mean weight loss of approximately 8% of their initial body weight, while those in the placebo group lost around 1% of their initial body weight. The study concluded that Contrave, in combination with lifestyle interventions, resulted in significant weight loss compared to a placebo. Another study published in the Obesity Journal examined the effects of Contrave on weight loss and metabolic parameters in obese or overweight individuals with type 2 diabetes. The participants received Contrave or a placebo for 56 weeks. The study reported that individuals treated with Contrave achieved a mean weight loss of approximately 6% of their initial body weight, compared to around 1% in the placebo group. 


Contrave, too, has its own set of safety considerations. Common side effects of Contrave include nausea, constipation, headache, and dizziness. In some cases, individuals may experience mood changes, such as irritability or depression, requiring close monitoring during treatment. As with any medication, it is important to consult a healthcare provider to assess the suitability of Contrave, especially for individuals with specific medical conditions or those taking other medications that may interact with its components.

Comparison and Considerations

Phentermine and Contrave are both viable options for weight loss management, but their mechanisms of action and profiles differ significantly. Phentermine primarily suppresses appetite, while Contrave combines appetite suppression with craving reduction and mood stabilization. Choosing between the two medications should be based on individual needs, medical history, and the guidance of a healthcare professional.

Typical Side Effects 

Phentermine: Prevailing after effects of Phentermine may include insomnia, dry mouth, increased heart rate, elevated blood pressure, restlessness, anxiety, and mood swings. It is not recommended for individuals with hypertension, cardiovascular disease, hyperthyroidism, or certain mental health conditions.

Contrave: Common side effects of Contrave include nausea, constipation, headache, dizziness, and potential mood changes such as irritability or depression. Close monitoring is required, especially for individuals with a history of mood disorders or those taking other medications that may interact with Contrave.

To Decide between Phentermine Vs Contrave

To sum up, when it comes to weight loss medications, Phentermine and Contrave offer distinct approaches to help individuals in their journey to achieve a healthier weight. Phentermine works by regulating appetite and increasing energy expenditure, while Contrave combines appetite suppression, cravings control, and mood stabilization. Both medications have shown effectiveness in short-term weight loss goals, but it’s important to remember that they should be used alongside lifestyle changes and under the guidance of a professional. Ultimately, the choice between Phentermine and Contrave should be based on individual needs and outcomes. By taking these factors into account, one can make informed decisions and embark on a weight loss journey that aligns with their unique circumstances and goals, paving the way to a healthier and happier life.